How much do you know about the raw materials of small nucleic acid drugs? A large supply of various types of nucleosides and their monomers

Release time:

2023-08-04 17:16

The efficient development and marketing of mRNA vaccines has led to the rapid development of the entire field of nucleic acid drugs, and nucleic acid drugs are one of the frontiers of biopharmaceuticals with clinical potential in the future! As a representative of nucleic acid drugs, small nucleic acid drugs show great potential

Small nucleic acid drugs, namely oligonucleic acid drugs, are short-chain nucleic acids composed of more than a dozen to dozens of nucleocapsid acids in series. At present, most oligonucleic acid drugs are synthesized by solid-phase phosphite chemical method. Among them, the preparation of core material nucleocapsidic acid monomer (nucleoccidiide monomer) is the key technology of solid-phase synthesis process and has high technical barriers.

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